The importance of Omega-9 for the reduction of Retinol hypersensitivity


Retinol (Vitamin A) is highly recognized as a very effective vitamin for anti-aging treatment due to its capacity to stimulate collagen production, accelerate cell-reproduction and normalize skin keratinization. Its regular application significantly improves skin elasticity, smoothness, and softness, resulting in younger, clearer, and healthier-looking skin.


Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by customers.




These burning, inflammation, and itch reactions resulted from the TRPV1 activation, which is an ion channel found in sensory neurons, that mediates the detection of noxious environmental stimuli in primary pathophysiological conditions. The activation of TRPV1 leads to a painful, burning sensation. Since these reactions are the main adverse effects of topical application of retinoids it is important to identify naturally antagonists of the TRPV1 channel and combine them in retinol formulations offering better customer compliance.


Omega-9 fatty acids are naturally occurring antagonists of the TRPV1 channel. By inhibiting TRPV1 in peripheral neurons, they partially block pain evoked by its agonists and itch evoked by histamine. Omega-9 series fatty acids (enriched in oleic acid and erucic acid) commonly come from plant oils and animal fat. Found naturally in the skin, oleic acid is known to have healing, regenerating, immunity, supporting, anti-microbial, and powerful absorption properties. An essential fatty acid, linoleic acid is known to play an important role in hydration, restoring the barrier function, skin brightening, and healing properties.



Collectively, these findings suggest that the combination of Retinol with Omega-9 enriched oils helps to reduce burning, and inflammation by lowering the TRPV1 activity underlying pain.  Resulting in a solution to treat retinoid-induced sensory hypersensitivity.


The development and subsequent production of a retinol product requires profound knowledge in the use of retinol. If this expertise is not available, the retinol product will not be sufficiently stable later on, the retinol will degrade, resulting in a decreased effectiveness of the product.


We at JW & Partner have over 25 years of experience in this specific field and the necessary scientific competency as well as the appropriate technology in our own laboratory to support you in bringing effective retinol products to the market. Do not hesitate to contact us for more details.



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